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Our lab focuses on understanding the fundamental role that cell-matrix and cell-cell interactions play in the myocardium and cardiovascular system. Specifically we focus on molecules instrumental in integrin-mediated adhesion and signaling, the focal adhesion / muscle costamere, and ones positioned in the intercalated disc of the myocyte. For this work we predominantly make use of genetically manipulated mouse models, cells derived from them and ancillary studies using primary or continuous cell lines. Our long term goals are to provide novel insights about mechanisms of normal cardiovascular development and growth, as well as identify novel therapies for a range of heart diseases.

Vinculin 3D cover Photo

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